Conference Abstracts

Yeh CY, Chang YC*. SLC25A11 reprograms energy metabolism and mitochondrial events to promote CCA tumorigenesis and inhibit ferroptosis. 38th Joint Annual Conference of Biomedical Science, Taipei, 2024. Honorable Mention

Lin BS, Cai HY, Chang YC. Overexpression of PFAS in urothelial carcinoma leads to proliferation and progression. Annual Academic Poster Seminar, Taipei, 2023. Outstanding Award

Lin BS, Cai HY, Chang YC. Overexpression of the de novo purine biosynthesis enzyme PFAS confers urothelial carcinoma proliferation and tumorigenicity via Myc positive feedback loop. Merck Young Scientist Award, Tainan, 2023. New Star Award

Lin BS, Cai HY, Chang YC. Same title. 37th Joint Annual Conference of Biomedical Science, Taipei, 2023. Selected Talk

Chang YC, Hsiao M. Loss-of-function Aldolase C hypermethylation causes serotonin production in glioblastoma. Annual Meeting at Experimental Biology, San Diego, 2020 (virtual).

Chang YC, Hsiao M. Interactions of Aldolase A with ATPase inhibitory factor 1 reprogram energy metabolism to maintain cancer stemness. Annual Meeting at Experimental Biology, Orlando, 2019.

Chang YC, Hsiao M. Non-enzymatic functions of Aldolase A induce Oct4 activation to promote lung cancer stemness. Annual Meeting at Experimental Biology, San Diego, 2018.

Chang YC, Hsiao M. Solute carrier family 2 member 4 regulates TRIM24-DDX58 axis to promote head and neck cancer metastasis. ASIP Annual Meeting, Chicago, 2017. Outstanding Graduate Study

Chang YC, Jan YH, Su CY, Hsiao M. Non-glycolytic function of Aldolase A promotes lung cancer metastasis through downregulation of PLD2 to activate PLD1. ASIP Annual Meeting, Boston, 2015.

Chang YC, Jan YH, Su CY, Hsiao M. Aldolase A interplays PLD1/2 activity through its enzyme-independent function to promote lung cancer metastasis. 30th Joint Annual Conference of Biomedical Science, Taipei, 2015.

Chang YC, Hsiao M. Identification of ALDOA as a new lung adenocarcinoma predictive gene involved in cancer metabolism and tumor metastasis. ASIP Annual Meeting, Boston, 2013.

Lin YY, Huang YT, Yang CJ, Huang CYF, Chang YC. IL-8 overcomes osimertinib resistance by inhibiting lung adenocarcinoma cell proliferation, tumoroid formation and tumorigenesis. Merck Young Scientist Award, 2025. Merit Award

Lin YY, Chang YC*. Compromised IL-8 overcomes osimertinib resistance by inhibiting NSCLC cells, tumoroid formation and suppressing tumorigenesis. 39th Joint Annual Conference of Biomedical Science, Taipei, 2025. 3rd Prize

Kuo HH, Lin YY, He ZJ, Chang YC*. ALDOA reprograms stemness and mitochondrial function in lung cancer by facilitating lactylation of m6A regulators. AACR, Chicago, 2025.

Kuo HH, Chang YC*. Radiation supports the chemotaxis of M1 macrophages against triple-negative breast cancer cells via the IKZF1–CCL5 axis. AACR, Chicago, 2025.

Yang YF, Chan MH, Chen CL, Hsiao M, Chang YC*. ALDOC as an indicator of HMGB1 blockade combined with checkpoint inhibitor-based immunotherapy in GBM patients. AACR, San Diego, 2024.

Chang YC, Chen CL. ALDOB regulates fructose metabolism to confer ferroptosis and immune response in colorectal cancer harboring microsatellite instability. AACR, San Diego, 2024.

Kuo HH, Tan CX, Tsai YC, Yeh CY, Chang YC*, Chuang HY. Radiation-modulated M1 macrophage polarization and enhanced phagocytosis against triple-negative breast cancer cells. 38th Joint Annual Conference of Biomedical Science, Taipei, 2024. 1st Prize

Cai HY, Lin BS, Chang YC. Estrogen receptor α inhibition enhances radiosensitization of breast cancer cells. 37th Joint Annual Conference of Biomedical Science, Taipei, 2023.

Li CH, Chan MH, Chang YC. ALDOC interplays with KIAA1409 to reduce m6A modifications and cancer-associated fibroblast characteristics in gliomas. AACR, Orlando, 2023.

Chang YC, Hsiao M. The effect of Aldolase C reflects the neurotransmitter secretion and PPARγ signaling in glioblastoma. Annual Meeting at Experimental Biology, Philadelphia, 2022.

Lin BS, Chang YC. Purine biosynthesis and related enzymes play the oncogenic function in FGFR3 mutant urothelial carcinoma. Annual Meeting at Experimental Biology, Philadelphia, 2022.

Lin BS, Chang ZX, Chang YC. V-ATPase family reflects radiosensitivity and neutralizes tumor-infiltrating lymphocytes of glioblastoma cells. 36th Joint Annual Conference of Biomedical Science, Taipei, 2022.

Cai HY, Chang ZX, Chang YC. Aldolase A induces Phospholipase D reprogram to resist alkylating agents and radiation in lung cancer cells. 36th Joint Annual Conference of Biomedical Science, Taipei, 2022.

Chang YC, Chan MS, Hsiao M. Tumor metastasis specific peptide-NIR persistent luminescence nanoparticles conjugated application: next-generation theranostic approach. FASMI, Taipei, 2020.

Chang YC, Chen MH, Hsiao M. Regorafenib targets YAP1 to inhibit epithelial-mesenchymal transition and cancer metastasis of cholangiocarcinoma. EORTC-NCI-AACR Symposium, 2020 (virtual).

Chen CL, Chang YC, Hsiao M. Rab GTPases accelerates GLUT4 translocation in colorectal cancer progression by insulin/IGF system. Annual Meeting at Experimental Biology, San Diego, 2020 (virtual).

Chang YC, Hsiao M. Overexpression of solute carrier family in ambient particulate matter exposure fibroblasts enhances lung cancer progression. Annual Meeting at Experimental Biology, San Diego, 2020 (virtual).

Tien CP, Chang YC, Hung SC, Hsiao M. PM2.5 activates Sirtuin-SREBP1-PIR axis to induce pulmonary fibroblast inflammation. Annual Meeting at Experimental Biology, Orlando, 2019.

Tseng YW, Chang YC, Hsiao M. Translocation and targeting of PGK1 to HTATSF1 regulate cancer cell metastatic ability. Annual Meeting at Experimental Biology, Orlando, 2019.

Chen CL, Chang YC, Hsiao M. Dystrophin promotes colorectal carcinoma metastasis and exosome secretion via protein–protein interaction with Rab GTPase 3C. Annual Meeting at Experimental Biology, Orlando, 2019.

Chang YC, Hsiao M. V-ATPase family regulates lysosomal exocytosis and neutralizes with tumor-infiltrating lymphocytes for glioblastoma cells. AACR Annual Meeting, Atlanta, 2019.

Chang YC, Hsiao M*. Glycolysis enzyme screenings identify non-glycolytic function of Aldolase A that interacts and alters F-actin dynamics to promote lung cancer metastasis. ELCC European Lung Cancer Congress, Geneva, 2018.

Tsai HF, Chang YC, Hsiao M*. Aldolase A triggers Oct4 activation to acquire lung cancer stem cell phenotypes through non-enzymatic functions. USCAP Annual Meeting, Vancouver, 2018.

Chang YC, Hsiao M. Hypoxia-mediated translational control of Hypoxia Inducible Factor 1 Alpha through Aldolase A feedback regulated in lung carcinogenesis. Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy, San Francisco, 2016.

Chang YC, Hsiao M. Therapeutic targeting of Aldolase A to inhibit metastatic ability via glycolysis-independent mechanism in lung cancer. Presentation of Investigators, Students and Academicians Annual Meeting, Houston, 2016.

Chang YC, Jan YH, Su CY, Hsiao M. PLD1 rather than PLD2 regulates lung cancer metastasis is dependent on non-enzymatic function of Aldolase A. 23rd Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, 2015.

Chang YC, Hsiao M. Glucose Transporter 4 drives head and neck cancer metastasis through TRIM24 signaling pathway. NDMC Retreat, Ilan, 2016.

Chang YC, Jan YH, Yang YF, Su CY, Lai TC, Hsiao M. Aldolase A induces invasion/metastasis of lung cancer through modulating HIF1-α and is a marker for poor clinical outcome. AACR Annual Meeting, San Diego, 2014.

SLC25A11-mediated reprogramming of mitochondrial redox state and lipid peroxidation confers NRF2-dependent ferroptosis resistance in biliary tract cancer. Central Taiwan Biliary Tract Cancer Forum, Nov 2025.

Uncovering the nonenzymatic role of ALDOA in lung cancer metastasis: a peptide-based molecular imaging approach. AACR on Campus Taiwan, Nov 2025.

The insights of multi-omics in cancer biology and its outlook in radiation therapy. Dept. of Health Technology and Informatics, The Hong Kong Polytechnic University, Oct 2022.

Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis. Dept. of Biotechnology and Laboratory Science in Medicine, NYCU, May 2022.

Omics-based platforms: current status and potential use for cholangiocarcinoma. The Gastroenterological Society of Taiwan, Linkou Chang Gung Memorial Hospital, Dec 2020.

Roles of aldolase family genes in human cancers and metabolic reprogramming. Kaohsiung Veterans General Hospital, May 2020.

Metabolic reprogramming in carcinogenesis and in human diseases. Kaohsiung Medical University, Dec 2019.

Multi-omics approaches to identify alterations of metabolic genes in cancer. Kaohsiung Medical University, Dec 2018.

Metabolic events in cancer. China Medical University, Sep 2018.

In-silico and in-tissue array-based discovery of metabolic reprogramming in human cancer. Kaohsiung Medical University, May 2017.

Array-based discovery and validation of new cancer biomarkers. National Yang-Ming University, Mar 2017.

ALDOA promotes metastatic progression via glycolysis-independent protein–protein interaction with γ-actin. Academia Sinica, Dec 2016.

Therapeutic targeting of Aldolase A/gamma-actin interaction inhibits lung cancer metastasis. National Defense Medical Center, Sep 2016.

ALDOA promotes metastatic progression via glycolysis-independent protein–protein interaction with γ-actin. National Cheng Kung University, Apr 2016.

Aldolase A in lung cancer. Taipei Medical University, Mar 2016.

High-throughput tissue array-based screens identifies metabolic reprogramming in lung cancer cells to promote metastasis and predicts poor outcome. Metabolic mini-symposium, National Yang-Ming University, Nov 2015.